论文部分内容阅读
为了解我国商品农药三氯杀螨醇是否具有明显的雌激素活性,利用整体给药方式检测了不同剂量三氯杀螨醇对未成熟小鼠子宫的作用.结果表明,较低剂量的三氯杀螨醇未使小鼠子宫明显增重,当剂量增加到4mg和8mg时,子宫重量明显增加,与对照组结果相比,有显著差异.将以上结果与雌二醇、o.p’DDT的作用进行了比较.本实验的结果说明三氯杀螨醇具有明显的雌激素活性.同时还表明小鼠子宫增重法对评价某些环境雌激素的雌激素生物活性来说是一种较为简便可靠的检测方法.
In order to find out whether dicofol of Chinese commercial pesticide has significant estrogenic activity, the effects of different doses of dicofol on the uterus of immature mice were tested by the mode of whole administration.The results showed that the lower dose of dicofol did not make mice’s uterus significantly increase, When the dose was increased to 4mg and 8mg, uterine weight increased significantly, compared with the control group, there are significant differences between the above results and estradiol, o.p’DTT were compared.The results of this experiment shows that dicofol Has obvious estrogenic activity.At the same time also shows that the mouse uterus weight gain method for the evaluation of some estrogen bioactivities of environmental estrogen is a relatively simple and reliable detection method.