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[目的]了解青少年慢性上消化道疾病患病情况,探讨治疗方法,为制订预防措施提供理论依据。[方法]2003～2004年,在济南市城区抽取5250名7～18岁在校中小学生进行调查,对查出的部分合并幽门螺杆菌感染的慢性上消化道疾病患者进行治疗,并进行为期5年的治疗效果观察。[结果]调查5250人,28.59%反复出现上消化道症状半年以上,从中抽取480例进行胃镜检查,确诊慢性上消化道病变者432例,其中浅表性胃炎238例,浅表性胃炎合并球炎80例,浅表性胃炎合并幽门口变形64例,胃多发性浅表溃疡28例,复合多发性浅表溃疡16例,球部溃疡6例。432例中,检出幽门螺杆菌感染者98例。家庭不和睦、单亲家庭、寄养、学习吃力、择校、家族史者所占比例,432例慢性上消化道疾病病例组均高于423名健康对照组(P<0.01);三口之家者所占比例,对照组高于病例组(P<0.01)。对98例合并幽门螺杆菌感染的慢性上消化道疾病患者中的97例进行治疗,4周疗程结束后1个月,有效率和幽门螺杆菌清除率治疗一组(47例)分别为95.74%、80.85%,治疗二组(22例)分别为72.72%、54.54%,差异有统计学意义(P<0.05)。疗后1个月、6个月、3年、5年复发率,治疗一组分别为4.44%、10.13%、28.88%、31.11%,治疗二组分别为6.25%、12.50%、43.75%、56.25%,差异均无统计学意义(P>0.05)。[结论]7～18岁中小学生慢性上消化道疾病患病率较高,胶体次碳酸铋、黄连素、庆大霉素治疗慢性上消化道疾病合并幽门螺杆菌感染的近期效果高于胶体次碳酸铋、羟氨苄青霉素、甲硝唑,但复发率均较高。
[Objective] To understand the prevalence of chronic upper gastrointestinal diseases among adolescents and to explore the treatment methods and provide a theoretical basis for the formulation of preventive measures. [Methods] From 2003 to 2004, 5250 school-age primary school students from 7 to 18 years old were selected in the urban area of Jinan City for investigation. Some patients with chronic upper gastrointestinal diseases complicated with Helicobacter pylori infection were treated and were treated for 5 Years of treatment effect observation. [Results] The survey of 5250 people, 28.59% of repeated upper gastrointestinal symptoms more than six months, from which 480 cases were taken gastroscopy, confirmed chronic upper gastrointestinal lesions in 432 cases, of which 238 cases of superficial gastritis, superficial gastritis with ball 80 cases of inflammation, superficial gastritis with pyloric deformity in 64 cases, multiple superficial gastric ulcer in 28 cases, multiple superficial ulcer in 16 cases, 6 cases of ulceration. In 432 cases, 98 cases of Helicobacter pylori infection were detected. The proportions of family disharmony, single-parent family, foster care, learning difficulties, school choice and family history were higher in 432 cases of chronic upper gastrointestinal diseases than in 423 healthy controls (P <0.01). The family of three The proportion was higher in the control group than in the case group (P <0.01). A total of 97 patients with chronic upper gastrointestinal diseases complicated by Helicobacter pylori infection were treated in this study. One month after the end of the 4-week treatment, the effective rate and the rate of Helicobacter pylori eradication in one group (47 cases) were 95.74% , 80.85% respectively. The two groups (22 cases) were 72.72% and 54.54% respectively, the difference was statistically significant (P <0.05). The recurrence rates at 1 month, 6 months, 3 years and 5 years after treatment were 4.44%, 10.13%, 28.88% and 31.11% respectively in the treatment group and 6.25%, 12.50%, 43.75% and 56.25 %, The difference was not statistically significant (P> 0.05). [Conclusion] The prevalence of chronic upper gastrointestinal diseases among primary school students and primary school students aged 7-18 years is high. The recent effect of colloidal bismuth subcarbonate, berberine and gentamycin in the treatment of chronic upper gastrointestinal diseases complicated by Helicobacter pylori infection is higher than that of colloid Bismuth carbonate, amoxicillin, metronidazole, but the recurrence rate was high.