从海洋天然产物中发现药物近年来再次引起广泛关注。2004年12月,美国FDA批准了第1个源自海洋生物的止痛药齐考诺肽(ziconotide,Prialt),用于治疗疼痛。2007年10月欧盟了第1个抗癌海洋药物海鞘素(ecteinascid in,Yondelis)。本文将举例说明影响药物发现的因素和要完成一种化合物从海洋到临床试验的飞跃会遇到的各种困难,展望未来,分析海洋药物的乐观前景。 The discovery of drugs from marine natural products has again drawn widespread attention in recent years. In December 2004, the U.S. FDA approved the first zopicotide, a marine-derived painkiller, to treat pain. October 2007 EU’s first anticancer marine drug, ecteinascid in (Yondelis). This article will illustrate the various factors that affect drug discovery and the difficulties in accomplishing the leap forward of a compound from the oceans to clinical trials. Looking ahead, we will analyze the optimistic outlook for marine drugs.