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缺氧诱导因子-1(hypoxia induc ib le factor-1,H IF-1)是特异性缺氧状态下发挥活性的一种转录因子。由Sem enza等[1]于1991年在肝细胞癌株Hep3b细胞核抽提物中发现。H IF-1在缺氧条件下广泛存在于哺乳动物和人体内许多类型的细胞内,可上调多种靶基因如促红细胞生成素、血管内
Hypoxia inducible factor-1 (HIF-1) is a type of transcription factor that plays an important role in hypoxia. Sem enza et al [1] in 1991 found in liver cell Hep3b nuclear extracts. HIF-1 is widely present in many types of cells in mammals and in humans under hypoxic conditions and can up-regulate a number of target genes such as erythropoietin, endovascular