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本文报道18例成人急性难治性白血病病人采用Vp-16与Ara-c组成的联合化疗方案治疗。经2~3个全疗程治疗后,10例难治性急淋中3例获CR、1例获PR;8例难治性急非淋中2例获CR、1例PR。在化疗中,全部病人白细胞均<4.0×109/L,17例病人有骨髓受抑,感染率为83.3%。此外,就Vp-16与Ara-c组成联合化疗方案对难治性急性白血病的疗效做一评述。
This article reports 18 cases of adult patients with acute refractory leukemia treated with Vp-16 and Ara-c combination chemotherapy. After 2 to 3 full courses of treatment, 3 of 10 refractory acute lymphoblastic leukemia patients were treated with CR, 1 with PR, and 8 with refractory urgency and nonclinical bleeding were treated with CR and 1 with PR. In chemotherapy, all patients with leukocytes <4.0 × 109 / L, 17 patients with bone marrow suppression, the infection rate was 83.3%. In addition, the combination of Vp-16 and Ara-c chemotherapy regimens in the treatment of refractory acute leukemia make a comment.