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目的探讨脓毒性休克患者血清presepsin与降钙素原(PCT)的相关性及对预后的影响研究。方法选取该院2013年1月—2015年11月收治的83例脓毒性休克患者,入住重症医学科后检测血清presepsin与PCT浓度,同时记录相关化验指标及患者基本情况,根据预后分为生存组及死亡组,比较二组presepsin与PCT的相关性,并先单因素后多因素分析对预后的影响。结果生存组及死亡组presepsin与PCT相关性分析,P<0.05有统计学意义,且r值均为00。PCT、CRP、乳酸浓度不是预后的独立危险因素(P>0.05)。结论脓毒性休克患者presepsin与PCT具有正相关性,presepsin是预后的独立危险因素,对预后的评估价值优于PCT。
Objective To investigate the correlation between serum presepsin and procalcitonin (PCT) in patients with septic shock and its prognosis. Methods Totally 83 patients with septic shock admitted to our hospital from January 2013 to November 2015 were enrolled in Department of Critical Care Medicine. Serum presepsin and PCT concentrations were measured. Relevant laboratory tests and basic information of patients were recorded. The patients were divided into survival group And death group. The correlation between presepsin and PCT in the two groups was compared. The prognosis was analyzed by multivariate analysis after univariate analysis. Results There was a significant positive correlation between presepsin and PCT in survival group and death group (P <0.05), and r values were all 0 0. PCT, CRP and lactate concentrations were not independent predictors of prognosis (P> 0.05). Conclusions There is a positive correlation between presepsin and PCT in patients with septic shock. Presepsin is an independent risk factor for prognosis and the prognostic value is better than that of PCT.