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为探讨狼疮性肾炎(LN)病人的淋巴细胞亚群和免疫球蛋白的变化及其相互关系,对60例LN进行了前瞻性研究。6咧中肾病综合征(NS)29例,非NS 31例。结果显示,LN病人CD3~++%CD4~+、CD16+CD56~+细胞比例明显减少,CD3~++CD8~+细胞比例明显增高,CD3~++CD4~+/CD3~++CD8~+<1(NS组P<0.01,非NS组P<0.05,且两组比较P<0.05):CD3~+、CD19~+无明显变化;血清IgE水平明显升高(NS组p<0.01,非NS组P<0.05,两组比较P<0.05),IgM、lgA水平也升高(p<0.05),NS组IgG明显降低,而非NS组明显升高;P均<0.01,两组比较P<0.01。结论:LN存在细胞免疫和体液免疫的异常,两者之间存在一定相互关系,CD3~++CD4~+/CD3~++CD8~+<1提示肾脏损伤。
To investigate the changes of lymphocyte subsets and immunoglobulins in patients with lupus nephritis (LN) and their correlations, 60 patients with LN were prospectively studied. 6 blanket nephrotic syndrome (NS) 29 cases, non-NS 31 cases. The results showed that the proportion of CD3 ~ + + CD4 ~ +, CD16 + CD56 ~ + cells in LN patients was significantly decreased and the proportion of CD3 ~ + + CD8 ~ + cells was significantly increased (P <0.01 for NS group, P <0.05 for non-NS group, P <0.05 for both groups): there was no significant change in CD3 +, CD19 + NS group, P <0.05, P <0.05), IgM, lgA levels also increased (p <0.05), NS group was significantly lower IgG, but non-NS group was significantly higher; P <0.01, P <0.01. CONCLUSION: LN has abnormal cellular immunity and humoral immunity. There is a certain correlation between LN and LN, and renal damage is indicated by CD3 ~ + + CD4 ~ + / CD3 ~ + CD8 ~ + <1.