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目的:分析研究经尿道前列腺电切联合内分泌治疗晚期前列腺癌的临床效果。方法:选取2009年10月-2012年12月的晚期前列腺癌患者50例,随机分为观察组和对照组各25例,两组患者均实施经尿道前列腺电切手术和双侧睾丸切除手术。观察组患者同时施加内分泌治疗,口服氟他胺,比较两组患者的临床疗效。结果:术后第6个月,观察组患者的膀胱残余尿量、前列腺特异抗原下降情况和最大尿流速、生活质量评分和前列腺症状评分均优于对照组(P<0.01),差异具有统计学意义。观察组患者在手术之后1年的生存率明显高于对照组(P<0.05),差异有统计学意义。结论:针对晚期前列腺癌患者实施经尿道前列腺电切术以及双侧睾丸切除术效果较好,安全可靠,加以内分泌治疗的疗效更好。
Objective: To analyze the clinical effect of transurethral resection of prostate combined with endocrine in the treatment of advanced prostate cancer. Methods: Fifty patients with advanced prostate cancer from October 2009 to December 2012 were randomly divided into observation group (25 cases) and control group (25 cases). Both groups underwent transurethral resection of prostate and bilateral orchiectomy. Patients in the observation group also received endocrine therapy and oral flutamide. The clinical efficacy of the two groups was compared. Results: At the 6th month after operation, the residual bladder volume, the decrease of prostate specific antigen and the maximum urinary flow rate, quality of life score and prostate symptom score in the observation group were better than those in the control group (P <0.01). The difference was statistically significant significance. The survival rate of observation group patients one year after operation was significantly higher than that of control group (P <0.05), the difference was statistically significant. Conclusion: Transurethral resection of the prostate and bilateral orchiectomy are effective and safe for patients with advanced prostate cancer. Endocrine therapy is more effective.