新生儿乙肝疫苗免疫接种首针“０”和第３针“６”保持不变，将第２针分为３０、４０、５０、６０天组，于第２针免后和全程免后１个月各采血检测，各组抗－ＨＢｓ阳转率和滴度均无组间差异。不论ＨＢｓＡｇ阴性和ＨＢｓＡｇ阳性母亲组的新生儿抗－ＨＢｓ消长变化均与０、１、６程序结果相似。提示对山区、海岛等受客观条件影响大的地区，新生儿乙肝疫苗第２针接种时间可在３０～６０天完成。 Neonatal hepatitis B vaccine immunization first needle “0” and the third needle “6” remained unchanged, the second needle into the 30,40,50,60-day group, after the first two needle-free and the whole after a free Month blood test, anti-HBs positive rate and titer in each group were no differences between groups. Both HBsAg-negative and HBsAg-positive mothers neonatal anti-HBs increase and decrease were similar to 0,1,6 program results. Prompted mountain, islands and other areas subject to objective conditions, neonatal hepatitis B vaccine needle 2 inoculation time can be completed in 30 to 60 days.