环孢霉素A是一种有效的免疫抑制剂,是目前肾脏移植术后抗排斥反应的主要药物。环孢霉素A的血浓浓度与免疫抑制作用的强度有关,也与肝、肾损害及其他毒性有关。该药生物利用度较低,肾移植患者平均为27％(5％～68％),个体差异大,易受很多因素影响。本文仅就常见影响环孢霉素A血药浓度的因素进行论述。 Cyclosporine A is a potent immunosuppressive agent and is the main drug for anti-rejection after renal transplantation. The concentration of cyclosporine A is related to the intensity of immunosuppression and also to liver and kidney damage and other toxicities. The drug has a low bioavailability, with an average of 27% (5% -68%) of kidney transplant recipients. Individuals vary greatly and are susceptible to many factors. This article discusses only the common factors that affect the plasma concentration of cyclosporin A are discussed.