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目的分析青中年冠心病患者中代谢综合征(MS)危险因素的分布与聚集状况,为早期防治干预提供依据。方法对103例青中年男性[年龄30～50(43.3±5.7)岁]冠心病患者及64例男性[年龄28～50(42.8±6.3)岁]冠状动脉造影正常的对照组的临床特征和生化特点进行比较。按照中华医学会糖尿病学分会标准诊断MS。结果两组在年龄上无差异。冠心病组的吸烟率显著高于对照组,但在冠心病家族史方面两组无差异。冠心病组的总胆固醇(TC)、餐后2h血糖(2hPBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)均显著高于对照组,而HDLC显著低于后者。冠心病组MS的发生率显著高于对照组(P<0.01)。Logistic回归分析显示,吸烟、低HDLC、HOMAIR、MS使青中年人冠心病患病的相对危险度增加。结论青中年冠心病患者多种代谢异常更加严重,对于青中年男性应重视MS的预防,以减少心血管事件的发生。
Objective To analyze the distribution and aggregation of risk factors of metabolic syndrome (MS) in young and middle-aged patients with coronary heart disease (CHD) and provide the basis for early prevention and treatment intervention. Methods The clinical features and clinical characteristics of 103 young and middle-aged male patients (aged 30-50 years (43.3 ± 5.7) years) and 64 male (aged 28-50 years (42.8 ± 6.3 years)] patients with coronary artery angiography Biochemical characteristics were compared. According to Chinese Medical Association Diabetes Branch standard diagnostic MS. Results There was no difference in age between the two groups. Smoking prevalence in CHD group was significantly higher than that in control group, but there was no difference in family history of CHD among the two groups. Total cholesterol (TC), postprandial 2h blood glucose (2hPBG), fasting insulin (FINS) and insulin resistance index (HOMAIR) in CHD group were significantly higher than those in control group, while HDLC was significantly lower than that in control group. The incidence of MS in CHD group was significantly higher than that in control group (P <0.01). Logistic regression analysis showed that smoking, low HDLC, HOMAIR, MS increased the relative risk of coronary heart disease in middle-aged adolescents. Conclusion Many kinds of metabolic abnormalities are more serious in young and middle-aged patients with coronary heart disease. For young and middle-aged men, the prevention of MS should be emphasized to reduce the occurrence of cardiovascular events.