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1957年Steiner等首次提出肝炎病毒可能为肝癌的病因。自后有许多成功的研究并指出,肝细胞癌(HCC)和慢性乙型肝炎病毒感染并存,慢性乙型病毒性肝炎被证明为肝癌的主要原因,提出了乙型病毒肝炎——大结节性肝硬化——肝细胞癌的假设。乙型肝炎病毒(HBV)与HCC的联合存在,可从以下几点得到认识:一、HCC时慢性HBV感染;二、临床和实验室证实HBV与HCC相关状态;三、HCC时HBV的病因作用;四、肝癌发病机制与HBV有关。一、肝细胞癌与慢性HBV感染:HCC时与HBV感染之间关系密切。通过大量的血清学研
Steiner et al. First proposed in 1957 that the hepatitis virus may be the cause of liver cancer. Since then, there have been many successful studies and pointed out that the coexistence of hepatocellular carcinoma (HCC) and chronic hepatitis B virus infection, chronic hepatitis B virus has been proven to be the main cause of liver cancer, proposed hepatitis B - large nodules Hypoxic cirrhosis - a hypothesis of hepatocellular carcinoma. The combined existence of Hepatitis B virus (HBV) and HCC can be recognized from the following points: First, chronic HBV infection in HCC; Second, clinical and laboratory confirmed status of HBV and HCC; Third, the etiological role of HBV in HCC ; Fourth, the pathogenesis of liver cancer and HBV. First, hepatocellular carcinoma and chronic HBV infection: HCC and HBV infection is closely related. Through a lot of serological research