肾小球硬化过程中，细胞外基质（ＥＣＭ）的合成与降解的研究近年来受到广泛的关注。体外研究证实，肾小球的３种固有细胞均能产生ＥＣＭ，其中以系膜细胞最强。在高糖刺激下，系膜细胞分泌ＦＮ明显增多，体内观察发现，组织器官硬化过程中，均有纤维连接蛋白（ＦＮ）等粘合蛋 In the process of glomerulosclerosis, the study of synthesis and degradation of extracellular matrix (ECM) has received extensive attention in recent years. In vitro studies have confirmed that the three types of glomerular intrinsic cells can produce ECM, of which the most mesangial cells. Under hyperglycemia stimulation, mesangial cells secrete FN significantly, and in vivo observations revealed that fibronectin (FN) and other binding eggs are present during hardening of tissues and organs.