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目的:研究香连丸对幽门结扎型胃溃疡大鼠的作用机理。方法:采用Shay-大鼠幽门结扎法。观察胃液中一氧化氮(NO)、前列腺素E2(PGE2)、表皮生长因子(EGF)含量的改变。结果:香连丸可使血清中PGE2浓度明显上升,其作用强度同西咪替丁(70 mg.kg-1)基本相同,而对EGF的影响不显著。同时,香连丸能使幽门结扎型消化性溃疡大鼠的胃液中NO含量显著增多,其作用强度同西咪替丁和胃康胶囊基本相同;结论:香连丸抗急性胃黏膜损伤可能与促进PGE2分泌与合成有关。并可能通过诱导一氧化氮合酶(NOS)催化生成NO来实现其抗溃疡作用。
Objective: To study the mechanism of action of Xianglian Pill on pylorus-ligated gastric ulcer rats. Methods: Shay-rat pylorus ligation was used. Observe the changes of nitric oxide (NO), prostaglandin E2 (PGE2) and epidermal growth factor (EGF) in gastric juice. RESULTS: Xianglian Pill could significantly increase the concentration of PGE2 in the serum. The effect was similar to that of cimetidine (70 mg.kg-1), but the effect on EGF was not significant. At the same time, Xianglian Pill can significantly increase the content of NO in the gastric juice of rats with pylori ligation-type peptic ulcer, and its effect intensity is basically the same as cimetidine and Weikang capsule. Conclusion: The anti-acute gastric mucosal injury of Xianglian Pill may be associated with Promote PGE2 secretion and synthesis. And it may be through the induction of nitric oxide synthase (NOS) catalytic NO to achieve its anti-ulcer effect.