近年来已有许多资料表明,中枢神经系统中的P物质(SP)参与心血管活动的调节。我们曾观察到,大鼠脑室注射SP引起升压,该作用可被阿片受体拮抗剂纳洛酮所阻断。本工作采用中枢微量注射各种阿片肽抗血清的方法,利用记录内脏交感神经放电、心率和血压指标进一步探讨阿片肽与SP在中枢升压作用中的关系。实验结果如下: In recent years, there is a lot of data showing that substance P (SP) in the central nervous system is involved in the regulation of cardiovascular activity. We have observed that intracerebroventricular (icv) injection of SP causes an increase in voltage, which can be blocked by the opioid receptor antagonist naloxone. In this work, a central micro-injection of various opioid peptide antiserum was used to further explore the relationship between opioid peptide and SP in central vasoconstriction by recording visceral sympathetic nerve discharge, heart rate and blood pressure. The experimental results are as follows: