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原肌球蛋白(TPM)是肌肉收缩过程中一种重要的调节蛋白,以多种异构体形式广泛存在于各种真核细胞中,并完成体内许多生命活动。TPM不仅对横纹肌、平滑肌收缩起调节作用,其所编码的基因突变与多种肌病的发生有关,而基因的表达异常更是与多种肿瘤的产生密不可分。因此,探究TPM致病的分子机制,对相关疾病的早期诊断及有效治疗均有重要现实意义。本文就TPM的结构特征及其在疾病发生发展中发挥的作用进行综述。
Tropomyosin (TPM) is an important regulatory protein in the process of muscle contraction. It exists widely in various eukaryotic cells in various isoforms and accomplishes many life activities in the body. TPM not only regulates the contraction of rhabdomyolus and smooth muscle, but also the gene mutations that it encodes with the occurrence of various myopathies. However, the abnormal gene expression is closely related to the production of many kinds of tumors. Therefore, exploring the molecular mechanism of TPM pathogenesis has important practical significance for the early diagnosis and effective treatment of related diseases. This article reviews the structural features of TPM and its role in the development of the disease.