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目的探讨非痴呆帕金森病患者轻度认知障碍与发病年龄和疾病阶段的关系。方法对84例非痴呆帕金森病患者按照患者发病年龄及疾病阶段分期,早期PD患者38例(早期PD组),晚期PD患者46例(晚期PD组),其中年轻早期PD患者23例(年轻早期PD组),老年早期患者15例(老年早期PD组),年轻晚期PD患者26例(年轻晚期PD组),老年晚期PD患者20例(老年晚期PD组)。选取同期门诊健康体检无神经系统阳性体征40例体检者作为对照组,进行神经心理学简易智能状态检查量表(MMSE)、蒙特利尔认知评价量表(MoCA)、Fuld物体记忆评价(FOM)、语言流畅性测验(RVR)、积木试验(BD)、数字广度测验(DS)及P300测试。结果 MMSE、MoCA、RVR、BD、DS、FOM对照疾病的阶段进展呈现下降趋势,P300PL呈现上升趋势,早期PD组、晚期PD组与对照组之间差异有统计学意义(P﹤0.05),年轻晚期PD组与年轻对照组之间差异有统计学意义(P﹤0.05),老年早期PD组、老年晚期PD组与老年对照组之间差异有统计学意义(P﹤0.05)。结论非痴呆帕金森病随着年龄的增加认知障碍状态有所下降,并且疾病晚期患者认知障碍状态比较疾病早期患者有所下降。
Objective To investigate the relationship between mild cognitive impairment and age of onset and stage of disease in non-demented Parkinson’s disease patients. Methods Eighty-four patients with non-demented Parkinson’s disease (PD), 38 patients with early PD (early PD) and 46 patients with advanced PD (late PD) were divided into two groups according to their age and stage of disease. Among them, 23 Early PD group), 15 cases of early elderly patients (early PD group), 26 cases of younger PD patients (younger PD group) and 20 cases of advanced PD patients (elderly patients with advanced PD group). Forty patients with positive neurological signs in the same period were selected as control group, and MMSE, MoCA, FOM, Language Fluency Test (RVR), Block Test (BD), Digital Breadth Test (DS), and P300 Test. Results The stages of MMSE, MoCA, RVR, BD, DS and FOM control showed a decreasing trend and P300PL showed an upward trend. There was a significant difference between the early PD group and the late PD group and the control group (P <0.05) The difference between the PD group and the young control group was statistically significant (P <0.05). The difference between the PD group and the control group was statistically significant (P <0.05). CONCLUSIONS: Non-demented Parkinson’s disease shows a decline in cognitive impairment with age, and cognitive decline in patients with advanced disease is lower in patients with early disease.