超顺磁性氧化铁纳米粒(SPION)作为一种新型纳米材料,具有超顺磁性、靶向性和良好的生物相容性。利用SPION的被动靶向和磁靶向的特点,使其在肿瘤部位富集,不仅作为磁共振成像(MRI)的造影剂用于临床肿瘤的早期诊断,还可作为抗肿瘤药物载体,将药物靶向递送到病灶部位,提高生物利用度,减少不良反应。该文综述了SPION在MRI造影和作为药物载体方面应用的研究进展。 Superparamagnetic iron oxide nanoparticles (SPION) as a new type of nano-materials, with superparamagnetism, targeting and good biocompatibility. The use of SPION passive targeting and magnetic targeting characteristics, make it enrichment in the tumor site, not only as a magnetic resonance imaging (MRI) contrast agent for the clinical diagnosis of early cancer, but also as an antitumor drug carrier, the drug Targeted delivery to the lesion site, improve bioavailability and reduce adverse reactions. This review summarizes the progress of SPION in the application of MRI and as a drug carrier.