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目的讨论并分析静脉用氟康唑在提前防治儿科重症细茵性肺炎长时间联合应用广谱抗生素后出现具有侵袭性真菌感染的临床的表现。方法从我院选取70例患有重症细菌性肺炎的患儿,任意的分成观察组和对照组各35例,观察组是采取预防性静脉用氟康唑的患儿,对照组是没有利用预防性静脉用氟康唑的患儿,回顾性对比研究两组患儿的临床方面的特征、侵袭性真茵感染的发生状态。结果两组患儿发生真菌感染的危险因素、临床特征不具有科学的统计学差异(P>0.05)。对照组发生侵袭性真菌感染5例(14.3%),预防组发生侵袭性真菌感染1例(2.9%),P<0.01,差异有科学性统计学意义。观察组和对照组肝功能情况无统计学差异。结论针对儿科重症细菌性肺炎长时间联合应用广谱抗生素的患儿,预防性静脉用氟康唑可很大程度降低发生侵袭性真菌感染的可能性,改变并完善预后,肝功能没有明显受到伤害。
Objective To discuss and analyze the clinical manifestations of intravenous fluconazole in the prevention and treatment of pediatric severe bacterial pneumonia in combination with broad-spectrum antibiotics for a long time with invasive fungal infection. Methods Seventy children with severe bacterial pneumonia were selected from our hospital and randomly divided into observation group and control group, 35 cases each. The observation group was prophylactic intravenous fluconazole. The control group did not use prevention Venous with fluconazole in children, retrospective study of two groups of children with clinical features, incidence of invasive true infection. Results The risk factors of fungal infection in the two groups were not statistically significant (P> 0.05). In the control group, invasive fungal infection occurred in 5 cases (14.3%), prevention group occurred invasive fungal infection in 1 case (2.9%), P <0.01, the difference was statistically significant. There was no significant difference in liver function between observation group and control group. Conclusions For pediatric patients with severe bacterial pneumonia combined with long-term broad-spectrum antibiotics, prophylactic intravenous fluconazole can greatly reduce the possibility of invasive fungal infection, change and improve the prognosis, liver function was not significantly hurt .