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目的:探讨血清中前列腺特异性抗原(t-PSA)、游离PSA(f-PSA)及f/t-PSA在前列腺增生(BPH)与前列腺癌(PCa)鉴别诊断中的意义。方法:应用放射免疫法检测90例BPH与PCa患者血清中的特异性抗原、游离PSA,并计算f/t-PSA比值。结果:血清PSA在4ng/mL~10ng/mL时,BPH与PCa组的特异性抗原含量差异无显著性(P>0.05),游离PSA、f/t-PSA比值差异有显著性(P<0.05)。结论:在BPH和PCa明显优于单纯使用特异性抗原,是早期诊断PCa的新参数,不但提高了PCa的检出率,也减少了不必要的前列腺穿刺活组织检查对患者造成的创伤和痛苦。
Objective: To investigate the significance of serum t-PSA, free PSA (f-PSA) and f / t-PSA in the differential diagnosis of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods: Serum specific antigens and free PSA were measured in 90 patients with BPH and PCa by radioimmunoassay, and the f / t-PSA ratio was calculated. Results: There was no significant difference in the specific antigen content between BPH and PCa (P> 0.05) and the difference of free PSA and f / t-PSA between the serum PSA level of 4ng / mL ~ 10ng / mL ). Conclusion: BPH and PCa were significantly better than the simple use of specific antigen, a new parameter for early diagnosis of PCa, which not only increased the detection rate of PCa but also reduced the trauma and pain caused by unnecessary prostate biopsy .