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目前采用基因重组等生物技术制备了大量的纯化亚单位疫苗或合成疫苗,这些疫苗的免疫原性很弱,需要佐剂的帮助才能有效地引发抗体应答。传统的佐剂具有很多本身无法克服的缺陷,促使人们研究开发新的佐剂系统。本文对双特异抗体的概念、T细胞在免疫应答中的作用及抗原的定向运送、双特异抗体介导的抗原定向运送及佐剂效应等方面对双特异抗体定向运送抗原作为一个新的佐剂系统给予了较为详细的阐述
At present, a large number of purified subunit vaccines or synthetic vaccines are prepared by using biological techniques such as gene recombination. The immunogenicity of these vaccines is very weak and the adjuvant is needed to effectively induce the antibody response. Traditional adjuvants have many inherently insurmountable shortcomings, prompting people to research and development of new adjuvant systems. In this paper, the concept of bispecific antibody, the role of T cells in immune response and the directional delivery of antigens, bispecific antibody-mediated delivery of the antigen and the adjuvant effect on the specific delivery of anti-SARS as a new adjuvant The system gives a more detailed description