根据Ｇｏｔｃｈ的肝素动力学模型，作者设计出逐段线性加权新模型，以计算肝素的消除速率常数（Ｋ）。用该模型对２６例血液透析（ＨＤ）肝素用量不稳定患者，在袖珍计算机床旁监控下进行了１００例次ＨＤ。基本上达到了ＨＤ中稳态的抗凝效果，并且避免了ＨＤ中患者出血，透析器和血液管道凝血等并发症。作者所设计的计算框图便于采用不同的计算机语言编制程序，以指导ＨＤ中肝素使用 According to Gotch’s heparin kinetic model, the authors devised a new piecewise linear-weighted model to calculate the heparin elimination rate constant (K). Using this model, 26 patients with unstable hemodialysis (HD) heparin were monitored 100 times HD with the help of a pocket computerized bed. The steady-state anticoagulant effect in HD is basically achieved and complications such as bleeding in patients with HD, coagulation in dialyzers and blood vessels are avoided. The authors designed a computational block diagram to facilitate the use of different computer language programming to guide HD heparin use