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脑垂体侵袭法是在乳腺癌行脑垂体摘除术后,无论肿瘤是否消退而能使癌痛消失这一事实启发下提出的。其中Marica 的脑垂体乙醇注入法(NALP)的镇痛率较高,对非激素依赖性癌除痛率仅次于激素依赖性癌。在其镇痛机制未明的情况下已被各国所采用。1981年在Verona 召开了以NALP 为主题的国际专题讨论会。作者自1977年以来与群马大学藤田達士教授合作对应用NALP 治疗癌痛的镇痛机制进行了临床研究。
The pituitary invasion method was inspired by the fact that the tumor pain disappeared whether or not the tumor disappeared after the pituitary gland was removed. Among these, Marica’s pituitary ethanol injection (NALP) has a higher rate of analgesia, and the hormone-dependent cancer elimination pain rate is second only to hormone-dependent cancer. It has been adopted by various countries in the absence of an analgesic mechanism. In 1981 an international symposium on the theme of NALP was held in Verona. Since 1977, the author has collaborated with Dr. Fujita University of Gunma University to conduct clinical research on the analgesic mechanism of NALP in the treatment of cancer pain.