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目的:研究腹腔区域性血流阻断动脉内介入化疗对机体循环系统的影响。对象与方法:16头幼猪分为两组,每组8头,分别行腹腔区域性血流阻断(Stop-flow,SF)及区域性血流阻断动脉内介入化疗(Stop-flow-Chemothera-py,SFC,MMC 0.2mg/kg)。术中监测心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)、肺动脉楔压(PAWP)、心排量(CO)、外周静脉阻力(SVR)及混合血氧饱和度(SvO2)。结果:两组实验动物术中的血流动力学指标均有较明显改变。血流阻断及再通后心率、心排量、血压、外周静脉阻力和混合静脉血氧饱和度(SvO2)有显著变化,阻断开放后PAWP有一过性升高,CVP术中无明显改变,血流再通20分钟左右上述指标均基本恢复至术前水平。SF与SFC两组间无明显差异。结论:腹腔区域性血流阻断动脉内介入化疗对循环系统有一定影响,但均在可控制范围,提示在临床应用是安全可靠的。
Objective: To study the effect of intra-abdominal regional blood flow blockade intra-arterial chemotherapy on the circulatory system. OBJECTIVES AND METHODS: Sixteen piglets were divided into two groups of 8 pigs each with intraperitoneal blockade (Stop-flow, SF) and regional blockade of intraarterial chemotherapy (Stop-flow- Chemothera-py, SFC, MMC 0.2 mg/kg). Intraoperative monitoring of heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), pulmonary arterial wedge pressure (PAWP), cardiac output (CO), peripheral venous resistance (SVR), and mixed oxygen saturation (SvO2) ). RESULTS: The hemodynamic parameters in the two groups of experimental animals had significant changes. There was a significant change in heart rate, cardiac output, blood pressure, peripheral venous resistance, and mixed venous oxygen saturation (SvO2) after blood flow blockade and recanalization. There was a transient increase in PAWP after blockade and no significant change in CVP during surgery. The above indicators returned to the preoperative level almost 20 minutes after the reflow of blood flow. There was no significant difference between SF and SFC groups. Conclusion: Intra-arterial intra-abdominal blood flow blocking intra-arterial chemotherapy has a certain effect on the circulatory system, but both are in a controllable range, suggesting that the clinical application is safe and reliable.