As the most influential strike-slip fault in East China,the Tancheng-Lujiang fault zone draws scholars attention for its strong seismic activity. Nevertheless,most research has been conducted along segments in Shandong Province and Bohai Bay where huge earthquakes occur frequently. Meanwhile,it is generally believed that segments lying to the south of Huaihe River have been inactive since the late Quaternary and thus it is incapable of generating moderate or strong earthquakes. However,these understandings about the Tancheng-Lujiang fault have been questioned by our recent work for part of the fault south to the Huaihe River. Based on interpretation of high-resolution satellite images,detailed field investigations near Wuhe county and Mingguang City in northern Anhui Province and elaborate microstructure analysis, we come to the conclusion that the Tancheng-Lujiang fault zone mainly consists of four branches and at least one should be active since the late Pleistocene for the Wuhe-Mingguang section. This segment is monopolized by dextral strike-slip motion in late Quaternary. Different from obvious faults in bed rocks or consolidated sediments,the latest activity trace in Quaternary loose sediment revealed by trench excavation is not obvious or even invisible to visual observation. According to our recent work and previous studies, we call for more attention to be paid to invisible faults in young sediment and also suggest that more research be conducted along this seemingly placid segment. As the most influential strike-slip fault in East China, the Tancheng-Lujiang fault zone draws scholars attention for its strong seismic activity. Nevertheless, most research has been conducted along segments in Shandong Province and Bohai Bay where huge earthquakes occur frequently. Meanwhile, it is generally believed that segments lying to the south of Huaihe River have been inactive since the late Quaternary and thus it is incapable of generating moderate or strong earthquakes. However, these understandings about the Tancheng-Lujiang fault have been questioned by our recent work for part of the fault south to the Huaihe River. Based on interpretation of high-resolution satellite images, detailed field investigations near Wuhe county and Mingguang City in northern Anhui Province and elaborate microstructure analysis, we come to the conclusion that the Tancheng-Lujiang fault zone mainly consists of four branches and at least one should be active since the late Pleistocene for the Wuhe-Ming This segment is monopolized by dextral strike-slip motion in late Quaternary. Different from obvious faults in bed rocks or consolidated sediments, the latest activity trace in Quaternary loose sediment revealed by trench excavation is not obvious or even invisible to visual observation. According to our recent work and previous studies, we call for more attention to be paid to invisible faults in young sediment and also suggest that more research be conducted along this seemingly placid segment