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神经干细胞对机体的自我修复起着重要的作用。脑损伤可以促发脑内神经干细胞增殖产生新生的神经元,神经生长类因子可以促进这种新生。并且,脑组织的损伤能够刺激新生神经元向损伤区迁移,迁移到损伤区的这些新生细胞有可能存活并分化为成熟细胞甚至整合进入局部的神经网络,从而帮助修复损伤的脑组织。由于这种反应尚不足以有效修复缺损的神经元,进一步明确脑损伤对内源性神经干细胞的影响将有助于找到合适的治疗措施刺激其增殖、迁移和分化从而有效促进神经功能的恢复。
Neural stem cells play an important role in the body’s self-repair. Brain damage can promote the proliferation of neural stem cells in the brain to produce newborn neurons. NGF can promote this newborn. Moreover, the damage of brain tissue can stimulate the migration of newborn neurons to the damaged area. These newborn cells migrating to the damaged area may survive and differentiate into mature cells or even integrate into the local neural network, thereby helping to repair damaged brain tissue. As this reaction is not enough to repair defective neurons, further clarifying the effect of brain injury on endogenous neural stem cells will help to find the appropriate therapeutic measures to stimulate proliferation, migration and differentiation so as to effectively promote the recovery of nerve function.