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近年来内眼手术的重大进展之一就是以透明质酸(HA)为辅助剂的眼科“粘性手术”(Viscosurgery)。瑞典产品Healon是用公鸡冠或人脐带制备的一种HA制剂,已被广泛应用于各种复杂的眼科手术及治疗骨关节炎中。以HA为主要成分的化妆品具有良好的保湿、润肤效果。我们从生产和应用出发,设计了牛眼玻璃体HA制备工艺,制备出了适于眼科及骨科应用的HA无菌制剂。通过理化分析,其质量基本上与Healon一致;眼科动物实验及临床试用表明,该制剂可用于眼科临床;我们还进行了骨科动物实验,观察了HA对兔膝
One of the major advances in intraocular surgery in recent years has been the ophthalmic “Viscosurgery” with hyaluronic acid (HA) as adjuvant. Swedish product Healon is an HA formulation prepared with a cock or human umbilical cord and has been used extensively in a variety of complex ophthalmic procedures and in the treatment of osteoarthritis. With HA as the main ingredient of cosmetics have good moisturizing, emollient effect. Based on the production and application, we designed the preparation technology of bovine vitreous HA and prepared aseptic HA preparations for ophthalmology and orthopedics. Through the physical and chemical analysis, its quality is basically consistent with Healon; ophthalmic animal experiments and clinical trials show that the preparation can be used in clinical ophthalmology; we also conducted an experimental orthopedic rabbits knee