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OLFM4GW112/hGC-1(olfactomedin 4,又名GW112,hGC-1)和GRIM-19(Genes assoeiated with retin-oid-IFN-induced mortality-19)是近年来发现的基因,它们通过多种机制来参与细胞凋亡。GW112是抗凋亡基因,促进肿瘤的生长,其在很多人类肿瘤中,特别是消化系统肿瘤中高表达。同时GW112与GRIM-19相互关联,而GRIM-19的正常表达可以维持细胞正常的生活周期,使细胞从衰老进入凋亡。近年来,GW112与GRIM-19受到人们的广泛关注,本文主要综述了二者与细胞凋亡的关系。
OLFM4GW112 / hGC-1 (olfactomedin 4, also known as GW112, hGC-1) and GRIM-19 (Genes with Ecto- oid-IFN-induced mortality-19) are found in recent years and are involved in many mechanisms Apoptosis. GW112 is an anti-apoptotic gene that promotes the growth of tumors, which is highly expressed in many human tumors, especially in digestive system tumors. At the same time, GW112 is associated with GRIM-19, while the normal expression of GRIM-19 can maintain the normal life cycle of cells and cause the cells to enter apoptosis from aging. In recent years, GW112 and GRIM-19 are widely concerned by people. This article mainly reviews the relationship between them and apoptosis.