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特发性肺纤维化(IPF)预后不良,至今尚无特效疗法,但怎样评价其预后?作者对此进行研究。 研究对象为1979～1991年间经开胸肺活检或剖检确诊的30例的IPF病人;男20例,女10例;年龄62.1±7.4岁,平均观察时间3.3年;对其中经3年观察后存活的14例和观察中因呼吸不全死亡的5例病人初诊时的背景因子、症状体征、临床检测所见统计学处理后进行比较分析。 结果 ①30例IPF病人平均生存时间为6.8年,3年生存率70％,5年生存率50％;死亡8例中6例在3年内死亡,死因呼吸不全6例(75％),肺癌和心肌梗塞各1例。②14例生存者和5例死亡者的临床材料经统
Idiopathic pulmonary fibrosis (IPF) poor prognosis, there is no specific therapy, but how to evaluate the prognosis? The authors study. The subjects were 30 IPF patients diagnosed by thoracotomy or autopsy from 1979 to 1991; 20 males and 10 females, aged 62.1 ± 7.4 years with an average observation time of 3.3 years. After 3 years of observation, 14 cases of survival and observation of 5 cases of death due to respiratory failure, the first visit of the background factors, symptoms and signs, clinical examination of statistical analysis after a comparative analysis. Results ①The average survival time of 30 IPF patients was 6.8 years, the 3-year survival rate was 70% and the 5-year survival rate was 50%. 6 of 8 deaths died within 3 years, 6 of death causes were respiratory insufficiency (75%), lung cancer and myocardium 1 case of infarction. ② 14 cases of survivors and 5 cases of death by clinical material system