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本文报道 1例 C 蛋白缺乏的脑血栓,并探讨其发病因素。病例报告女性,39岁。因突发左侧轻偏瘫、感觉障碍和构音障碍于1990年1 O月29日入院。患者于3年前确诊为Ⅱ期乳癌而行左侧乳癌根治术,术后一直口服氟尿嘧啶衍化物作辅助化疗。体检:肥胖,血压120/68mmHg,心率71次/min,无心律失常。心音、呼吸音清晰,无肝、脾肿大。无血管病危险因素。既往无血管病史。家族史:其父在第三次心肌梗塞时死亡,其叔父猝死原因不明。其母及同胞无血栓病史。患者脑 CT 显示右侧顶叶新鲜梗塞。大脑数字减影血管造影显示右侧大脑中动脉前分支闭塞,但侧支循环尚好。二维超声心动图和彩色多普勒超声心动图未见心瓣膜疾病、血栓形成或心
This article reports a case of protein C deficiency in cerebral thrombosis, and explore the pathogenesis. Case report Female, 39 years old. Hemiplegia on the left side of the sudden onset, sensory disturbances and dysarthria were admitted on January 29, 1990. The patient was diagnosed with stage II breast cancer three years ago and underwent radical mastectomy for left breast cancer. Oral fluorouracil derivatives were given as adjuvant chemotherapy after surgery. Physical examination: obesity, blood pressure 120 / 68mmHg, heart rate 71 beats / min, no arrhythmia. Heart sound, breath sounds clear, no liver, splenomegaly. Vascular risk factors. No history of previous vascular disease. Family history: His father died of a third myocardial infarction and his uncle’s sudden death was unknown. Its mother and siblings without a history of thrombosis. Patient brain CT showed a fresh infarct in the parietal lobe. Digital subtraction angiography of the brain showed occlusion of the anterior branch of the middle cerebral artery, but collateral circulation was good. Two-dimensional echocardiography and color Doppler echocardiography No heart valve disease, thrombosis or heart