观察11例血栓性血小板减少性紫癜(TTP)急性期病人血浆,和从1例急性期TTP患者血浆中提纯的血小板聚集蛋白对12名健康志愿者,5例恢复期TTP病人血小板以及兔、大鼠和猴血小板的致聚作用,发现在程度和性质上均存在明显的个体差异。在聚集活性较强的6组TTP血浆-人血小板中,进一步观察几种抑制物对TTP血浆诱发血小板聚集的影响,结果在阐明本病发病机理的多元论和临床治疗的个体化方面有实际的意义。 Eleven patients with thrombotic thrombocytopenic purpura (TTP) in the acute phase of plasma and 12 healthy volunteers, 5 patients with convalescent TTP and platelet aggregation in plasma from one patient with acute TTP were observed. Synergistic aggregation of rat and monkey platelets revealed significant individual differences in both extent and nature. Further investigation of the effect of several inhibitors on platelet aggregation induced by TTP in aggregating the more active 6 TTP plasma-human platelets was of practical significance in elucidating the pathogenesis of this disease and the individualization of clinical treatment .