胃复安(灭吐灵、Metoclopramide、PrimperanMaxolon、Paspertinum)是治疗消化功能异常的常用药物,并广泛应用于多种原因引起的呕吐。晚近报道有1%胃复安服用者出现以急性肌张力障碍为主的锥体外系反应,尤其多见于儿童。但小剂量胃复安致严重锥体外系者报道甚少,而伴有呼吸困难者尚未见有报道。现将我们遇到的2例报道如下。例1 女,23岁。因服用乙烯雌酚出现恶心、呕吐,口服用胃复安10毫克,每日2次。于第3次服药(总量仅30毫克)半小时后,突然出现头颈部活动障碍,接着出现颈背部肌肉强直性收缩,头固定于过度后仰、眼球上吊固定,继之,又出现头颈部过度左后或右后仰,呈阵发性加剧。此时患者感呼吸困难,以致患者须张口呼吸,即此亦感气短,同时出现面肌抽搐,下颌抽动,口角左斜,闭口困难,舌肌发硬,双下肢静止性震颤。查体:心肺无异常,神清,双下肢 Metoclopramide (Metoclopramide, PrimpenMaxolon, Paspertinum) is a commonly used drug for the treatment of abnormal digestive function, and is widely used in vomiting caused by a variety of reasons. Recently reported that 1% of patients taking metoclopramide with acute dystonia-based extrapyramidal reactions, especially more common in children. However, small doses of metoclopramide caused by very little extrapyramidal reports, while those with dyspnea have not been reported. Now we have encountered two cases reported below. Example 1 Female, 23 years old. Due to taking diethylstilbestrol nausea, vomiting, oral metoclopramide 10 mg, 2 times a day. Half an hour after the third dose (only 30 mg total), sudden head and neck movement disorders, followed by neck dorsiflexion ankylosis contraction, head fixed in the excessive backwards, the eye hanging fixed, followed by the head again Excessive neck left or right back, was paroxysmal increase. At this time, the patient feels dyspnea, so that the patient should open his mouth to breathe, which is also a sense of shortness of breath, while facial muscle spasms, mandibular twitch, mouth left oblique, difficulty in closing, tongue hard, resting tremor in both lower extremities. Physical examination: no abnormal heart and lungs, God clear, both lower extremities