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自身免疫性肝炎(AIH)是T细胞介导的一种慢性肝脏炎症性疾病,以肝脏特异性组织学改变、高免疫球蛋白、循环自身抗体及对免疫抑制剂治疗有反应为其主要特征,基因易感性、病毒分子模拟、自身免疫反应等均被认为与AIH发病机制相关,目前AIH的治疗以抑制肝脏免疫反应为主,但AIH的发病机制至今仍尚未完全明确。Th17细胞为近年来新近发现的Th辅助细胞,它所分泌的细胞因子在多种自身免疫性疾病中均有不同程度的升高,虽然在肝脏疾病中的作用仍处于研究阶段,但Th17的发现无疑对免疫介导的肝脏疾病乃至AIH发病机制的进一步研究有所帮助,也为疾病的治疗提供了新的线索。
Autoimmune hepatitis (AIH) is a T cell-mediated chronic inflammatory disease of the liver characterized by liver-specific histological changes, high immunoglobulins, circulating autoantibodies and responses to immunosuppressive agents, Genetic susceptibility, molecular modeling of viruses and autoimmune reactions are considered to be related to the pathogenesis of AIH. At present, the treatment of AIH is mainly to inhibit the liver immune response, but the pathogenesis of AIH is still not yet fully understood. Th17 cells are newly discovered Th helper cells in recent years. The secreted cytokines are variously elevated in many autoimmune diseases. Although the role of Th17 cells in liver diseases is still under study, the discovery of Th17 Undoubtedly immune-mediated liver disease and even further study of the pathogenesis of AIH help, but also provide new clues for the treatment of diseases.