目的探讨单点双注法制备帕金森病(Parkison’s disease,PD)大鼠模型的可行性。方法分别以两点法和单点双注法注射6-羟基多巴胺(6-OHDA)于纹状体,研究二者模型成功率、平均转速与酪氨酸羟化酶(tyrosine hydroxylase,TH)阳性细胞数。结果单点双注法与两点法大鼠模型成功率、平均转速与TH阳性细胞数无显著性差异。结论6-OHDA纹状体单点双注法制备PD大鼠模型是可行的。 Objective To investigate the feasibility of single point double injection in the preparation of rat model of Parkinson’s disease (PD). Methods The 6-hydroxydopamine (6-OHDA) was injected into the striatum by the two-point method and the single point double-injection method respectively. The success rate of the model and the average rotational speed were compared with the positive rate of tyrosine hydroxylase (TH) Cell number. Results The single point double-injection method and two-point rat model success rate, average speed and TH positive cells no significant difference. Conclusion 6-OHDA single striatal double-injection method for the preparation of PD rat model is feasible.