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月经过多是临床常见的症状,其会诊率为3.07%。Gestrinone(G)是具有雄激素,抗雌激素,抗孕激素作用的制剂19-去甲睾酮衍生物,与下丘脑和垂体类固醇受体互相作用可降低促卵泡成熟激素和黄体生成素的分泌。但是用G减少月经失血和引起闭经尚无客观的证据。本试验目的为检查G能否减少月经过多(>80ml)患者的血丢失。作者选择37例34～46岁的患者,主诉为月经周期规则失血过多而无月经间出血者。妇科检查及宫内膜活检无异常,月经周期第三周血浆孕激素水平和排卵相一致。用碱性正铁血红素技术测量月经失血(MBL)。在宫内膜活检第4周期测出血量以避免活检对MBL的影响。测量出血前患者禁用PG
Menorrhagia is a common clinical symptoms, the consultation rate was 3.07%. Gestrinone (G) is a 19-nortestosterone derivative with androgenic, anti-estrogen and anti-progestin effects that interacts with the hypothalamus and pituitary steroid receptors to reduce the secretion of follicle stimulating hormone and luteinizing hormone. But with G to reduce menstrual blood loss and cause amenorrhea there is no objective evidence. The purpose of this test is to check if G can reduce blood loss in menorrhagia (> 80ml). The authors selected 37 patients 34 to 46 years of age, the main complaint for the menstrual cycle rules excessive bleeding without inter-menstrual bleeding. Gynecological examination and endometrial biopsy was normal, the third week of menstrual cycle plasma progesterone levels and ovulation consistent. Menstrual blood loss (MBL) was measured with alkaline heme. The amount of blood was measured during the fourth cycle of endometrial biopsy to avoid the impact of biopsy on MBL. PG was disabled before measurement of bleeding