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目的讨论临床鼻腔鼻窦罕见非上皮组织恶性肿瘤的临床特征、诊断及治疗。方法对１９８６～１９９８年诊治鼻腔鼻窦非上皮组织恶性肿瘤１６例分类，就组织切片、临床诊断和治疗进行回顾性分析。结果鼻腔鼻窦恶性淋巴瘤３例，髓外浆细胞瘤２例，纤维肉瘤２例，胚胎性横纹肌肉瘤１例，恶性黑色素瘤３例，恶性混合瘤１例，恶性肉芽肿４例。综合治疗后随访，８例存活３～５年，其中恶性淋巴瘤２例，恶性黑色素瘤１例，髓外浆细胞瘤２例，恶性肉芽肿３例。结论此类肿瘤特点：①不易明确诊断，易与其它肿瘤相混淆。②多易复发及全身转移。③临床病理学诊断及组织学分类较困难，④综合治疗有益于改善预后。
Objective To discuss the clinical features, diagnosis and treatment of rare non-epithelial malignant tumors in clinical nasal sinuses. Methods From 1986 to 1998, 16 cases of non-epithelial malignant tumors of the nasal cavity and nasal cavity were classified. The histological sections, clinical diagnosis and treatment were retrospectively analyzed. Results 3 cases of malignant lymphoma of nasal sinuses, 2 cases of extramedullary plasmacytoma, 2 cases of fibrosarcoma, 1 case of embryonic rhabdomyosarcoma, 3 cases of malignant melanoma, 1 case of malignant mixed tumor and 4 cases of malignant granuloma. After comprehensive treatment, 8 patients survived 3 to 5 years, including 2 malignant lymphoma, 1 malignant melanoma, 2 extramedullary plasmacytoma and 3 malignant granuloma. Conclusions The characteristics of such tumors: ① not easily diagnosed, easily confused with other tumors. ② more easy to relapse and systemic transfer. ③ clinicopathological diagnosis and histological classification is more difficult, ④ comprehensive treatment is beneficial to improve the prognosis.