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目的探讨慢性乙型肝炎患者血清HBs Ag水平与HBV DNA定量、HBe Ag滴度的关系。方法选取2013年5月至2015年5月郑州市第七人民医院收治的120例慢性乙型肝炎患者,收集其HBs Ag阳性血清,采用荧光定量聚合酶链反应检测HBV DNA载量,化学发光微粒子免疫分析法定量检测HBV标志物滴度,观察HBV DNA定量与HBe Ag滴度、HBs Ag水平之间的相关性,并采用SPSS14.0统计学分析。结果不同HBs Ag水平组间ALT水平、HBe Ag滴度、HBV DNA定量比较,差异有统计学意义(P<0.05);不同HBV DNA定量组间HBe Ag滴度、HBs Ag水平比较,差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者血清HBs Ag、HBV DNA、HBe Ag三项指标均呈一定的相关性,利于指导临床制定合适治疗方案。
Objective To investigate the relationship between serum HBsAg level and HBV DNA quantification and HBeAg titer in patients with chronic hepatitis B Methods A total of 120 patients with chronic hepatitis B who were admitted to the Seventh People’s Hospital of Zhengzhou City from May 2013 to May 2015 were enrolled in this study. HBsAg positive serum was collected. Fluorescent quantitative polymerase chain reaction was used to detect HBV DNA load. Chemiluminescent microparticles Immunoassay was used to detect the titer of HBV markers. The correlation between HBV DNA and HBeAg titer and HBsAg level was observed and analyzed by SPSS14.0. Results There was significant difference in ALT level, HBeAg titer and HBV DNA quantification between HBs Ag groups (P <0.05). HBeAg titer and HBs Ag level among different HBV DNA groups were statistically different Significance (P <0.05). Conclusion The three indexes of HBs Ag, HBV DNA and HBe Ag in serum of patients with chronic hepatitis B have a certain correlation, which will help guide the clinical development of appropriate treatment.