论文部分内容阅读
应用放射免疫法测定８例精神分裂症患者及其性别、年龄配对的正常人脑脊液（ＣＳＦ）８肽胆囊收缩素（ＣＣＫ—８）的免疫反应活性，观察了患者在氟哌啶醇治疗６周后ＣＳＦ中ＣＣＫ—８免疫反应活性的变化，以及他们治疗前后２４小时尿ＭＨＰＧ排泄量的变化。结果发现，患者基础状态下ＣＳＦＣＣＫ—８显著低于与其性别、年龄配对的正常人。经６周氟哌啶醇治疗后患者ＣＳＦＣＣＫ—８显著增高，接近正常对照组。治疗前ＣＳＦＣＣＫ—８与ＳＡＮＳ评分呈显著负相关，而与ＳＡＰＳ评分呈显著正相关。正常对照组及患者治疗后的ＣＳＦＣＣＫ—８免疫反应活性与年龄皆呈高度正相关。文章就精神分裂症与ＣＳＦＣＣＫ—８的关系进行了讨论
Radioimmunoassay was used to measure the immunoreactivity of 8 human cholestin (CCK-8), a normal human cerebrospinal fluid (CSF), in 8 schizophrenic patients and their gender and age. The effects of haloperidol on 6 weeks Post-CSF CCK-8 immunoreactivity changes, and 24 hours before and after treatment, urinary MHPG excretion changes. The results showed that CSFCCK-8 was significantly lower in patients with basal state compared with their gender, age matched normal people. After 6 weeks of haloperidol treatment CSFCCK-8 patients was significantly higher, close to the normal control group. Before treatment CSFFSK-8 was significantly negatively correlated with SANS score, but positively correlated with SAPS score. CSFCCK-8 immunoreactivity in normal control group and patients after treatment was highly positively correlated with age. The article discusses the relationship between schizophrenia and CSFCCK-8