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目的探讨前列腺素E-1对过度膨胀所致肺损伤的保护作用及作用机制.方法杂种犬16只,随机分为对照组和实验组,建立犬肺过度膨胀动物模型.对照组:保持肺过度膨胀6h;实验组:保持肺过度膨胀6h并经股静脉以30ng/(kg·min)的剂量给予PGE-1,用微量泵持续给药.两组6h内均进行连续的肺动脉
Objective To investigate the protective effect and mechanism of prostaglandin E-1 on lung injury induced by over-expansion.Methods 16 dogs were randomly divided into control group and experimental group to establish animal models of over-expansion of canine lungs.Control group: The rats in the experimental group were inflated for 6h and the PGE-1 was given via the femoral vein at a dose of 30ng / (kg · min), and the rats were continuously administered with the micropump.The continuous pulmonary artery