目的通过体外与体内药敏试验的研究，探索有效的方法，指导临床药物的筛选．方法利用９２株幽门螺杆菌（Ｈｐ）体外培养进行西药及中药体外药敏试验．通过１４Ｃ尿素呼气体试验对１２６例患者进行体内中西药物药敏试验，并对体内外药物药敏试验进行比较．结果体外药敏试验ＣＢＳ、四环素、呋喃唑酮、中药（胃病冲剂）及其中甲、乙药等显著抑菌．体内药敏试验显示胃病冲剂、甲、乙药、小剂量三联疗法（ＣＢＳ、四环素和小剂量呋喃唑酮）Ｈｐ清除率分别为６６６７％，６３６４％，５８５５％及７５０％．显著高于其余药物．结论体内外药敏试验多数情况下结果一致，对临床用药有较好的指导作用．但少数情况下两者存在差异．根据体内药敏试验选择药物更为可靠 Objective To explore effective methods to guide the selection of clinical drugs through the in vitro and in vivo susceptibility testing. Methods 92 strains of Helicobacter pylori (Hp) were cultured in vitro and Western medicine and Chinese medicine in vitro susceptibility testing. Through the 14 C urea breath test on 126 patients in vivo drug susceptibility testing of Chinese and Western medicine, and drug susceptibility testing in vivo and in vitro were compared. Results In vitro susceptibility test CBS, tetracycline, furazolidone, Chinese medicine (stomach granules) and A, B and other significant antibacterial. In vivo susceptibility testing showed that the Hp clearance rates of gastric granules, A, B and small dose triple therapy (CBS, tetracycline and low dose furazolidone) were 6667%, 6364%, 5855% and 750% respectively, . Significantly higher than the rest of the drug. Conclusion In vitro and in vivo susceptibility testing results are consistent in most cases, the clinical medication has a good guiding role. However, there are a few differences between the two. Drug susceptibility testing based on the choice of drugs more reliable