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肿瘤的血管系统已成为一个有希望的、新的抗癌治疗靶点。原发性肿瘤的生长和转移都依赖于来源于即存血管的新生血管的形成,这个过程叫做血管生成。抑制血管生成,把肿瘤血管作为靶点就能有效地控制肿瘤的生长。已开发出一些天然和合成化合物,目前正处于临床前和临床研究阶段。本文旨在提供对具有抗血管生成活性的化合物的概述和该类药物早期临床试验的经验
The vascular system of the tumor has become a promising new anti-cancer therapeutic target. The growth and metastasis of primary tumors are dependent on the formation of new blood vessels derived from the existing blood vessels. This process is called angiogenesis. Inhibiting angiogenesis and targeting tumor vasculature can effectively control tumor growth. Some natural and synthetic compounds have been developed and are currently in preclinical and clinical research. The purpose of this article is to provide an overview of compounds with antiangiogenic activity and experience in early clinical trials of such drugs.