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目的:观察高血压伴高血脂患者采用联合用药的临床治疗方法及效果。方法:将我院2011年3月~2013年3月接待的高血压伴高血脂患者86例作为研究对象,回顾性分析他们的临床资料,随机均分为研究组与对照组,各自43例患者,其中对照组单纯采用氨氯地平阿托伐他汀治疗,研究组则采用联用药物治疗,即缬沙坦联合辛伐他汀治疗。对两组患者的治疗效果进行观察分析及对比,其中着重对比两组患者治疗前后的舒张压、收缩压、TG(甘油三酯)、TC(血清总胆固醇)等情况。结果:两组患者在治疗后,前述各个指标皆有明显降低,同治疗前相较差异性显著(P<0.05);两组患者治疗后各项指标对比无显著性差异(P>0.05),无统计学意义;研究组患者治疗中出现不良反应1例,而对照组则出现6例,两组不良反应发生情况差异性显著(χ2=9.03,P<0.01)。结论:针对高血压伴高血脂患者采用缬沙坦联合辛伐他汀治疗,可以取得比较良好的临床效果,并且安全性较好,值得临床推广及应用。
Objective: To observe the clinical treatment and effect of combination therapy in patients with hypertension and hyperlipidemia. Methods: 86 cases of hypertensive patients with hyperlipidemia admitted from March 2011 to March 2013 in our hospital were retrospectively analyzed. The clinical data were divided into study group and control group randomly. Each of the 43 patients , In which the control group was treated with amlodipine atorvastatin alone and the study group was treated with combination of drugs, valsartan and simvastatin. The therapeutic effects of two groups of patients were observed and analyzed, and compared. The diastolic blood pressure, systolic blood pressure, TG (triglyceride) and TC (serum total cholesterol) were compared between the two groups before and after treatment. Results: After treatment, the above indexes were significantly decreased in both groups (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05) There was no significant difference between the two groups. One case of adverse reactions occurred in the study group while 6 cases of the control group showed significant difference (χ2 = 9.03, P <0.01). Conclusion: The combination of valsartan and simvastatin in hypertensive patients with hyperlipidemia can achieve a relatively good clinical effect, and is safe and worthy of clinical promotion and application.