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目的探讨血清降钙素原(PCT)在新生儿感染性疾病中的临床诊断效果。方法 30例感染性疾病新生儿作为实验组,选择同期入院的30例非感染患儿作为对照组,采用全自动免疫荧光分析仪、半定量固相免疫测定患儿血清降钙素原水平;采用全自动生化分析仪、免疫散射比浊法测定患儿C反应蛋白(CRP)水平,比较两组诊断相关指标。结果实验组PCT水平为(5.7±4.3)μg/L、CRP水平为(17.5±12.4)mg/L,高于对照组[PCT水平为(0.4±0.5)μg/L、CRP水平为(3.4±4.2)mg/L](P<0.05);PCT最佳临界值为0.51μg/L,低于CRP(8.01 mg/L)(P<0.05);PCT灵敏度为91.3%,高于CRP(P<0.05);PCT特异度为75.6%,阳性预测值为75.3%,低于CRP(P<0.05);PCT阴性预测值为88.1%,约登指数为0.63,高于PCT(P<0.05)。结论新生儿感染性疾病中采用血清降钙素原诊断效果理想,更加有助于新生儿早期感染性疾病诊断,值得推广使用。
Objective To investigate the clinical diagnostic value of serum procalcitonin (PCT) in neonatal infectious diseases. Methods Thirty newborns with infectious diseases were selected as the experimental group. Thirty non-infected children were enrolled in the same period as the control group. Serum procalcitonin levels were measured by semi-quantitative immunosorbent assay with automatic immunofluorescence analyzer. The level of C-reactive protein (CRP) in children was detected by automatic biochemical analyzer and immunostaining turbidimetry. The relative indexes of the two groups were compared. Results The PCT level in the experimental group was (5.7 ± 4.3) μg / L and the CRP level was (17.5 ± 12.4) mg / L, higher than that in the control group [PCT level was (0.4 ± 0.5) μg / 4.2) mg / L] (P <0.05). The optimal cutoff value of PCT was 0.51μg / L, lower than that of CRP (8.01 mg / L) (P <0.05) 0.05). The PCT specificity was 75.6%, the positive predictive value was 75.3%, which was lower than CRP (P <0.05). The PCT negative predictive value was 88.1%, the Youden index was 0.63, higher than that of PCT (P <0.05). Conclusions The serum procalcitonin in neonatal infectious diseases is effective in diagnosing neonatal infectious diseases and is worth promoting.