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目的探讨生长抑素(SS)在胃癌发生发展中的作用及地位,从而为胃癌的治疗和预后判断提供一个新的途径。方法应用免疫组化SABC(strept avidin biotin complex)法检测78例胃癌组织和20例正常胃黏膜中SS和表皮生长因子受体(EGFR)的表达。结果SS在正常胃黏膜中阳性表达率为85.0%,胃癌组织中阳性表达率为24.3%;高/中分化组和低分化组中的阳性表达率分别为34.2%、13.5%,随分化程度减低而呈下降趋势;浸润黏膜层或黏膜下层和浸润肌层或浆膜层两组的阳性表达率分别为64.3%、15.6%,随浸润程度的加深其阳性表达率呈下降趋势;无淋巴结转移组和有淋巴结转移组的阳性表达率分别为38.7%、14.9%;在TNMⅠ~Ⅱ期和Ⅲ~Ⅳ期此两组中的阳性表达率分别为45.5%、8.9%。以上两组间比较差异均有统计学意义(P<0.05)。SS的阳性表达与EGFR的阳性表达呈负相关系。结论SS的低表达与胃癌的组织学分级、浸润深度、淋巴结转移及TNM分期密切相关。SS可能通过抑制EGFR的表达而抑制胃癌的生长。
Objective To investigate the role and position of somatostatin (SS) in the development of gastric cancer, and to provide a new approach for the treatment and prognosis of gastric cancer. Methods The expressions of SS and epidermal growth factor receptor (EGFR) in 78 gastric cancer tissues and 20 normal gastric mucosa were detected by immunohistochemical SABC (strept avidin biotin complex) method. Results The positive expression rate of SS in normal gastric mucosa was 85.0%, while the positive expression rate in gastric carcinoma was 24.3%. The positive rates of SS in high / moderately differentiated and poorly differentiated groups were 34.2% and 13.5%, respectively, which decreased with the degree of differentiation But showed a downward trend. The positive expression rates of infiltrating mucosa or submucosa and infiltrating myometrium or serosal layer were 64.3% and 15.6% respectively. The positive rate of invasion decreased with the increasing of infiltration degree. No lymph node metastasis And lymph node metastasis were 38.7% and 14.9% respectively. The positive expression rates in TNM Ⅰ ~ Ⅱ and Ⅲ ~ Ⅳ stages were 45.5% and 8.9% respectively. The difference between the two groups was statistically significant (P <0.05). The positive expression of SS was negatively correlated with the positive expression of EGFR. Conclusion The low expression of SS is closely related to histological grade, depth of invasion, lymph node metastasis and TNM stage in gastric cancer. SS may inhibit the growth of gastric cancer by inhibiting the expression of EGFR.