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目的 探讨我国不同肝病患者血清铜蓝蛋白 (CP)水平交叉程度 ,为肝豆状核变性(WD)的诊断和鉴别诊断提供科学的依据。方法 测定 90 5例正常人、WD及其他各种肝病患者血清CP水平 ,采用SPSS12统计软件进行统计分析。结果 WD患者血清CP平均为 (93 9± 98 1)mg/L ,与其他各组相比差异有非常显著性 ,72 7%的患者低于 10 0mg/L ,其中 4 2 9%的患者低于 5 0mg/L ,但是也有 9 1%的患者其血清CP正常 ,其中 3例高于 4 0 0mg/L ,最高达 5 0 1mg/L。 6 8%的非WD患者血清CP低于正常 ,最低为 2 8mg/L。急性肝炎患者血清CP平均为 (398 4± 15 1 3)mg/L ,显著高于其他各组。重型肝炎患者血清CP平均为 (2 96 5± 10 6 5 )mg/L ,显著低于其他各组 ,其中18 8%的患者低于正常。结论 WD患者CP水平显著低于正常人和其他肝病患者 ,但是与其他肝病有一定程度的交叉 ,单凭CP水平不足以确诊或排除WD。
Objective To investigate the level of serum ceruloplasmin (CP) levels in patients with different liver diseases in China and provide a scientific basis for the diagnosis and differential diagnosis of hepatolenticular degeneration (WD). Methods The levels of serum CP in 905 normal subjects, WD and other liver diseases were measured and analyzed by SPSS12 statistical software. Results The average serum CP of WD patients was (93 9 ± 98 1) mg / L, with significant difference compared with other groups, 72 7% of patients were lower than 100 mg / L, of which 42.9% were low Serum CP was normal in 50 mg / L, but also 91% of the patients, 3 of which were higher than 400 mg / L and up to 500 mg / L. Sixty-eight percent of non-WD patients had a serum CP lower than normal, with a minimum of 28 mg / L. Serum CP in patients with acute hepatitis averaged (398 4 ± 15 1 3) mg / L, significantly higher than the other groups. Serum CP in patients with severe hepatitis was (2 96 5 ± 10 6 5) mg / L on average, significantly lower than the other groups, with 18.8% of the patients being below normal. Conclusions The level of CP in WD patients is significantly lower than that in normal subjects and other liver diseases, but there is some degree of cross-over with other liver diseases. Only the level of CP is not enough to confirm or exclude WD.