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目的本研究通过对比血管内皮生长因子(VEGF)、可溶性血管内皮生长因子受体-1(sFlt-1)水平差异与新生儿出生体重的关系,以探讨其在胎儿出生体重发生中的作用。方法采用免疫组织化学法检测40例分娩正常出生体重儿组(AGA组)、30例高出生体重儿组(LGA组)及30例低出生体重儿组(SGA组)胎盘组织中VEGF、sFlt-1的表达水平。结果①LGA组胎盘组织中VEGF的表达高于AGA组,sFlt-1的表达水平低于AGA组,差异有统计学意义(χ2=21.17,P<0.01)。SGA组胎盘组织中VEGF的表达低于AGA组,sFlt-1的表达水平高于AGA组,差异有统计学意义(χ2=8.44,P=0.04)。②胎盘组织中VEGF的表达水平与胎儿出生体重呈正相关(r=0.427,P<0.01),胎盘组织中sFlt-1的表达水平与胎儿出生体重呈负相关(r=-0.569,P<0.01)。结论孕妇胎盘组织中VEGF及sFlt-1表达水平的变化可能与胎儿出生体重有关。
OBJECTIVE: To investigate the role of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor-1 (sFlt-1) levels in the development of newborn birth weight. Methods Immunohistochemical method was used to detect the expression of VEGF, sFlt-1 in placentas from 40 normal birth weight infants (AGA group), 30 high birth weight infants (LGA group) and 30 low birth weight infants (SGA group) 1 expression level. Results ① The expression of VEGF in placenta of LGA group was higher than that in AGA group, while the expression of sFlt-1 was lower than that in AGA group (χ2 = 21.17, P <0.01). The expression of VEGF in SGA group was lower than that in AGA group, and the expression level of sFlt-1 was higher than AGA group (χ2 = 8.44, P = 0.04). The expression of VEGF in placenta was positively correlated with fetal birth weight (r = 0.427, P <0.01). The expression of sFlt-1 in placenta was negatively correlated with fetal birth weight (r = -0.569, P <0.01) . Conclusion The expression of VEGF and sFlt-1 in placenta of pregnant women may be related to the birth weight of the fetus.