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FurchgottandZawadzkifirstdemonstratedthatthevasodilationinducedbyacetylchoIineisendotheli-um-derivedrelaxingfactor(EDRF)andEDRFisquitelikelynitricoxide(NO)-NOissynthesizedfromvascll-larendothelialcellbytheaminoacidL-ArgandthesynthesisofNOisstereospecifica