目的探讨早孕妇女在笑气无痛人流术前直肠给药米索前列醇扩张宫颈口的适宜剂量,了解用药后扩宫效果及副反应。方法选择900例未经阴道分娩,自愿行笑气无痛人工流产、无禁忌证、孕40￣60天的妇女,随机分为3组,每组在笑气吸入无痛人流术前直肠给药米索前列醇分别为200ug、400ug、600ug,观察不同剂量给药后孕妇腹痛、阴道流血、流产、术中宫颈口扩张程度、镇痛效果及术中出血情况。结果米索前列醇用量越大宫颈口扩张越好,但术前腹痛、阴道流血、流产等不良反应越重,各组术中疼痛及出血量无明显差异。400ug组宫颈扩张效果满意、并发症少、安全。结论笑气吸入人工流产术前2￣3小时直肠给药米索前列醇400ug,扩宫满意,镇痛效果好,并发症少,受术者易接收,设备及方法简单,安全、可靠,价格便宜,稳定性好,值得推广。 Objective To investigate the appropriate dosage of misoprostol for cervical dilatation of cervix in early pregnant women before painless abortion, and to understand the effect and adverse reactions of dilatation after dosing. Methods Nine hundred and nine non-vaginal deliveries were performed. Voluntary painkillers were used to induce painless abortion without contraindications. Women of 40-60 days gestation were randomly divided into 3 groups. Each group was given rectal Misoprostol were 200ug, 400ug, 600ug, observed after different doses of pregnant women abdominal pain, vaginal bleeding, abortion, intraoperative cervical dilatation, analgesic effect and intraoperative bleeding. Results The greater the dosage of misoprostol was, the better the cervix was. However, the more severe adverse reactions such as abdominal pain, vaginal bleeding and miscarriage before operation were, the pain and blood loss in each group were not significantly different. 400ug cervical dilatation satisfactory results, fewer complications, safety. Conclusions Inhalation of induced abortion 2 to 3 hours prior to the operation of rectal administration of misoprostol 400ug, the expansion of the palace satisfied with good analgesic effect, fewer complications, easy to receive by the surgeon, equipment and methods are simple, safe, reliable, and price Cheap, good stability, worth promoting.