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目的 :探讨P -选择素与乳腺癌浸润、转移的关系。方法 :运用免疫组织化学SP法分别检测 2 5例乳腺纤维腺瘤、2 8例乳腺导管内癌、5 0例浸润性导管癌组织中P -选择素的表达情况。结果 :乳腺纤维腺瘤、乳腺导管内癌、浸润性导管癌组织中P -选择素的阳性表达率分别为 12 .0 % ( 3 /2 5 )、3 9.3 % ( 11/2 8)、74.0 % ( 3 7/5 0 ) ,三组间两两比较均有统计学意义 (P <0 .0 5 )。且其表达与肿瘤浸润、淋巴结转移有关 (P <0 .0 5 )。结论 :提示P -选择素参与了乳腺癌的发生、发展、浸润及淋巴结转移 ,有望成为预测乳腺癌转移和评估预后的重要指标。
Objective: To investigate the relationship between P - selectin and infiltration and metastasis of breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of P - selectin in 25 cases of breast fibroadenoma, 28 cases of intraductal carcinoma and 50 cases of invasive ductal carcinoma. Results: The positive rates of P - selectin in breast fibroadenoma, intraductal carcinoma and invasive ductal carcinoma were 12.0% (3/25), 33.3% (11/2 8), 74.0 % (3 7/5 0). There was a statistically significant difference between the three groups (P <0.05). And its expression was related to tumor infiltration and lymph node metastasis (P <0.05). Conclusion: P - selectin is involved in the occurrence, development, invasion and lymph node metastasis of breast cancer, which may be an important index for predicting the metastasis and assessing the prognosis of breast cancer.