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复合蛇毒急性毒性实验,小鼠灌胃给药的 LD_(50)为121.45±0.22mg/kg 体重,腹腔给药的LD_(50)为1.23±0.06mg/kg 体重。大鼠长期毒性实验分别灌胃给药5,10及20mg/kg 体重,对照组给予等容积的蒸馏水,连续6个月。高剂量组5只动物死亡(12.5%),并有两肺出血斑点。病理报告高剂量组有轻度心肌细胞浊肿、肝内胆管周围炎性变化,中、低剂量组无明显改变.高剂量组存活动物于停药30天后,各项指标及病理检查均正常。
The acute toxicity test of compound snake venom showed that the LD_ (50) of intragastric administration in mice was 121.45 ± 0.22mg / kg body weight and the LD 50 of intraperitoneal administration was 1.23 ± 0.06mg / kg body weight. Long-term toxicity in rats were administered intragastrically 5,10 and 20 mg / kg body weight, the control group was given an equal volume of distilled water for 6 months. Five animals died in the high-dose group (12.5%) with bleed spots on both lungs. Pathological reports of high-dose high-dose group of mild cardiomyocyte turbidity, intrahepatic bile duct inflammatory changes, medium and low dose group no significant change in high-dose group of animals after 30 days withdrawal, the indicators and pathological examination were normal.